| | | | Introduction to FISH – Microscopy | |  |
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 | | Fluorescence in situ hybridization | |  back
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 Deutsche Version |
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| | allows the direct localization of DNA and RNA sequences on chromosomes, in cells and in tissue. This technology is based on the hybridization between target sequences of the single-strand DNS of chromosomes or cell nuclei with labelled complementary specimens. The signal is intensified by means of specific fluorochrome-labelled antibodies and visualized in the microscope. | |
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| | | This technique allows, for example, the localization of genes and also the direct morphological detection of genetic defects causing hereditary diseases. | | |
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| | | Other applications:
- detection of diagnostically significant aneuploids, e.g. trisomy 21
- chromosome painting
- interphase cytogenetics
- CGH method (Comparative Genomic Hybridization)
- Prenatal diagnostics
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